Neoadjuvant FOLFOX Chemotherapy for Patients With Locally Advanced Colon Cancer

Summary

The main cause of recurrence after surgical treatment of colon cancer is distant metastasis. Neoadjuvant chemotherapy has potential benefits of improving the effectiveness of chemotherapy. Preoperative chemotherapy may eradicate microscopic metastatic cancer cells earlier than adjuvant chemotherapy, reduce cancer cell spillage during surgery, and lessen the invasiveness of surgical resection. This randomized multicenter phase III trial is assessing whether preoperative chemotherapy improves oncologic outcomes of patients with locally advanced colon cancer.

Timeline

Start

2020-10-23

Primary completion

2028-12-28

Completion

2031-12-28

Drugs

Indications