The Effect of Losartan on Emotional Processing in Healthy Volunteers

Completed 30 enrolled University of Oxford

RandomizedParallel-groupDouble-blindBasic science

Summary

This experimental medicine study explores whether a single dose of losartan (50mg) versus placebo affects the processing of positive and negative stimuli, using fMRI.

Timeline

Start: 2016-06-01
Primary completion: 2017-06-30
Completion: 2017-06-30

Publications

Reinecke A, Browning M, Klein Breteler J, Kappelmann N, Ressler KJ, Harmer CJ, Craske MG. Angiotensin Regulation of Amygdala Response to Threat in High-Trait-Anxiety Individuals. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Oct;3(10):826-835. doi: 10.1016/j.bpsc.2018.05.007. Epub 2018 Jun 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Losartan	Other / unclassified	50 mg	Oral

Indications

No indication recorded.