Network-Level Effects of Nitrous Oxide in the Human Brain

Phase 4 Completed 21 enrolled University of Michigan

NaSingle-groupOpen-labelBasic science

Summary

The purpose of this study is to understand how a commonly used drug, nitrous oxide, acts on the brain to reduce pain. Nitrous oxide is commonly used in anesthesiology but there is limited knowledge on how this drug affects functional networks in the brain.

Timeline

Start: 2017-07-21
Primary completion: 2019-10-11
Completion: 2019-10-11

Publications

Dai R, Larkin TE, Huang Z, Tarnal V, Picton P, Vlisides PE, Janke E, McKinney A, Hudetz AG, Harris RE, Mashour GA. Classical and non-classical psychedelic drugs induce common network changes in human cortex. Neuroimage. 2023 Jun;273:120097. doi: 10.1016/j.neuroimage.2023.120097. Epub 2023 Apr 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nitrous Oxide	Other / unclassified	35 %	Inhaled

Indications

No indication recorded.