drugset / Trial / NCT03454243

Oral Immunomodulatory Tyrosine Kinase Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors

NCT03454243 ↗

Phase 0 Terminated 1 enrolled Hoffmann-La Roche
NaSingle-groupOpen-labelTreatment

Summary

This is a first-in-human, open label, multicenter, dose escalation study of RXDX-106 in patients with locally advanced or metastatic solid tumors, who have no available therapy likely to convey clinical benefit. This study will examine the safety, tolerability, pharmacokinetics (PK), pharmacodynamics and preliminary efficacy of RXDX 106.

Timeline

Start
2018-02-15
Primary completion
2018-06-05
Completion
2018-06-05

Outcome

Outcome not reported

Stopped: “Sponsor's decision”

Drugs

EvaluationDrugModalityDoseRoute
Subject CEP-40783 Small molecule 10 mg Oral

Indications

No indication recorded.