Botox Injections for Patients With Persistent Facial Pain

Phase 2 Completed 31 enrolled Norwegian University of Science and Technology St. Olavs Hospital · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The main objective of this study is to investigate efficacy and safety of injecting botulinum toxin towards the sphenopalatine ganglion using MultiGuide in patients with persistent idiopathic facial pain

Timeline

Start: 2018-05-01
Primary completion: 2021-11-23
Completion: 2021-11-23

Outcome

Missed primary endpoint

paper In weeks 5-8, there was no statistically significant difference in average pain intensity between BTA versus placebo (0.00; 95% CI = -0.57 to 0.57) (P = 0.996). PMID 37435807 ↗

Publications

Jamtoy KA, Thorstensen WM, Stovner LJ, Rosen A, Maarbjerg S, Bratbak D, Simpson MR, Tronvik E. Onabotulinum toxin A block of the sphenopalatine ganglion in patients with persistent idiopathic facial pain: a randomized, triple-blind, placebo-controlled, exploratory, cross-over study. Cephalalgia. 2023 Jul;43(7):3331024231187132. doi: 10.1177/03331024231187132.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Botulinum toxin type A	Protein / enzyme biologic	25 iu	Other