drugset / Trial / NCT03468231
HAIC of FOLFOX vs. HAIC of OXA for Advanced HCC
Phase 3
Unknown
300 enrolled
Sun Yat-sen University
Dongguan People's Hospital · collabFirst Affiliated Hospital Xi'an Jiaotong University · collabFirst Affiliated Hospital, Sun Yat-Sen University · collabGuangzhou No.12 People's Hospital · collabKaiping Central Hospital · collabThe First Affiliated Hospital of University of South China · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
The purpose of this study is to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) of oxaliplatin plus fluorouracil/leucovorin compared with HAIC of oxaliplatin alone in patients with hepatocellular carcinoma (HCC) with major portal venous tumor thrombus (PVTT).
Timeline
- Start
- 2018-03-09
- Primary completion
- 2019-09-09
- Completion
- 2020-03-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Leucovorin | Small molecule | — | Other |
| Comparator | fluorouracil | Small molecule | — | Other |
| Comparator | Oxaliplatin | Small molecule | — | Other |
| Background | Sorafenib | Small molecule | 400 mg | Oral |