drugset / Trial / NCT03468933
Fibrinolysis Compared to Thoracoscopy for Pleural Infection
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator (TPA) and human recombinant Deoxyribonuclease (DNase) for the management of empyema or complicated parapneumonic effusion (CPPE) in adults.
Timeline
- Start
- 2017-11-01
- Primary completion
- 2019-12-30
- Completion
- 2019-12-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Alteplase | Protein / enzyme biologic | 10 mg | Other |
| Comparator | DESOXYRIBONUCLEASE | Protein / enzyme biologic | 5 mg | Other |