drugset / Trial / NCT03473093
Oral Pregabalin Effect to the Intravenous Morphine in Multiple Fracture Ribs
RandomizedParallel-groupTriple-blindTreatment
Summary
Determine the effect of using oral pregabalin on the analgesic effects of IV infusion of morphine in patients with multiple fracture ribs.
Timeline
- Start
- 2018-03
- Primary completion
- 2019-03
- Completion
- 2019-04
Publications
- Background Cannon RM, Smith JW, Franklin GA, Harbrecht BG, Miller FB, Richardson JD. Flail chest injury: are we making any progress? Am Surg. 2012 Apr;78(4):398-402.
- Background Katz J, Jackson M, Kavanagh BP, Sandler AN. Acute pain after thoracic surgery predicts long-term post-thoracotomy pain. Clin J Pain. 1996 Mar;12(1):50-5. doi: 10.1097/00002508-199603000-00009.
- Background Jensen MP, Karoly P, Braver S. The measurement of clinical pain intensity: a comparison of six methods. Pain. 1986 Oct;27(1):117-126. doi: 10.1016/0304-3959(86)90228-9.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Pregabalin | Small molecule | 150 mg | Oral |
| Comparator | Morphine | Other / unclassified | 20 ug/kg | Intravenous |
Indications
No indication recorded.