Usefulness of Lidocaine in Oral and Maxillofacial Surgeries Under General Anesthesia for Pain Control After Operation

Summary

This will be a randomized double blinded clinical study conducted in patients undergoing oral and maxillofacial surgery under general anesthesia. Lidocaine group will receive intravenous bolus 1.5 mg/kg at induction followed by continuous infusion of 2 mg/kg/hr until the completion of surgery.Normal saline group will receive same amount of intravenous normal saline .The primary outcome will be postoperative pain using the NRS scale during first 24 hours and time to first analgesic request

Timeline

Start

2018-03-28

Primary completion

2018-12-27

Completion

2019-03-27

Outcome

Missed primary endpoint

paper does not have significant effect on reduction in postoperative pain intensity and analgesic consumption PMID 39376771 ↗

Publications

• Mahato VK, Dongol A, Acharya P, Yadav AK, Subedi A, Jaisani MR. "Can Perioperative Intravenous Lidocaine Decrease Postoperative Pain After Oral and Maxillofacial Surgeries?": A Randomized Clinical Trial. J Maxillofac Oral Surg. 2024 Oct;23(5):1240-1247. doi: 10.1007/s12663-022-01831-1. Epub 2022 Dec 20.

Drugs

Indications