Study to Evaluate the Effect of Coadministered Erythromycin on the Pharmacokinetics and Safety of Padsevonil

Phase 1 Completed 28 enrolled UCB Biopharma S.P.R.L.

NaSequentialOpen-labelBasic science

Summary

The purpose of this study is to evaluate and compare the Pharmacokinetics (PK) of concomitant administration of Padsevonil (PSL) in the presence and absence of erythromycin in healthy study participants.

Timeline

Start: 2018-03-27
Primary completion: 2018-08-02
Completion: 2018-08-02

Publications

Chanteux H, MacPherson M, Kramer H, Otoul C, Okagaki T, Rospo C, De Bruyn S, Watling M, Bani M, Sciberras D. Overview of preclinical and clinical studies investigating pharmacokinetics and drug-drug interactions of padsevonil. Expert Opin Drug Metab Toxicol. 2024 Aug;20(8):841-855. doi: 10.1080/17425255.2024.2373108. Epub 2024 Jul 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Erythromycin	Small molecule	500 mg	Oral
Subject	Padsevonil	Small molecule	100 mg	Oral

Indications

No indication recorded.