Atezolizumab + Stereotactic Radiation in Triple-negative Breast Cancer and Brain Metastasis

Summary

This research study is studying the combination of a drug called atezolizumab and a radiation procedure called stereotactic radiosurgery (SRS) as a possible treatment for triple-negative breast cancer that has spread to the brain. The interventions involved in this study are: * Atezolizumab * Stereotactic radiosurgery (SRS)

Timeline

Start

2018-05-01

Primary completion

2019-11-21

Completion

2025-11-12

Publications

• Giordano A, Graham N, Aizer AA, Tayob N, Pereslete AM, Schoenfeld JD, Leone JP, Davis R, Erick TK, Mayer EL, Winer EP, Krop I, Tolaney SM, Lin NU. A phase II study of atezolizumab in combination with stereotactic radiation for patients with triple-negative breast cancer and brain metastasis. Breast Cancer Res Treat. 2026 Mar 7;216(2):24. doi: 10.1007/s10549-026-07932-6.

Drugs

Indications