Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

Phase 1 Recruiting 20 enrolled University of Louisville

NaSingle-groupOpen-labelTreatment

Summary

Compare the efficacy and tolerability of IRE in combination with either FOLFIRINOX or gemcitabine in patients with locally advanced pancreatic cancer.

Timeline

Start: 2018-05-30
Primary completion: 2026-07-31
Completion: 2027-07-31

Publications

Bhutiani N, Li Y, Zheng Q, Pandit H, Shi X, Chen Y, Yu Y, Pulliam ZR, Tan M, Martin RCG 2nd. Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma. Ann Surg Oncol. 2020 Oct;27(11):4348-4359. doi: 10.1245/s10434-020-08782-2. Epub 2020 Jul 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Gemcitabine	Small molecule	25 %	—
Subject	Gemcitabine	Small molecule	50 %	—
Subject	Gemcitabine	Small molecule	75 %	—
Subject	Irinotecan	Small molecule	—	—
Subject	Leucovorin	Small molecule	—	—
Subject	Oxaliplatin	Small molecule	—	—
Subject	fluorouracil	Small molecule	—	—

Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

Summary

Timeline

Publications

Drugs

Indications