drugset / Trial / NCT03505853
A Study to Investigate the Interaction Between Givosiran and a 5-probe Drug Cocktail in Patients With Acute Intermittent Porphyria (AIP)
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to evaluate the effect of givosiran on the pharmacokinetics of the 5-probe cocktail of midazolam, caffeine, losartan, omeprazole, and dextromethorphan, and their metabolites, in asymptomatic patients with Acute Intermittent Porphyria.
Timeline
- Start
- 2018-04-26
- Primary completion
- 2018-11-16
- Completion
- 2019-01-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Caffeine | Small molecule | — | — |
| Subject | Dextromethorphan | Unknown | — | — |
| Subject | Givosiran | Small interfering RNA (siRNA) | — | Subcutaneous |
| Subject | Losartan | Other / unclassified | — | — |
| Subject | Midazolam | Small molecule | — | — |
| Subject | Omeprazole | Other / unclassified | — | — |