Metformin Therapy in Non-diabetic AAA Patients

Summary

A prospective randomized, double blind, placebo-controlled, safety and efficacy study of metformin as add-on therapy in abdominal aortic aneurysm (AAA) OBJECTIVES Primary Objective * To demonstrate treatment efficacy of metformin in AAA in comparison to placebo or active comparator, as measured by growth of the AAA maximum diameter at 12 months Secondary Objectives * To asses inflammatory cytokines and parameters of neutrophil activation in AAA in response to metformin treatment by glucose * insulin * Interleukin-6 * markers of neutrophil activation (MPO, elastase, NGAL)

Timeline

Start

2018-09-26

Primary completion

2024-05-01

Completion

2024-05-01

Publications

• Background minimale Endnote Formatierung der Refs im Word Dokument probieren!!!
• Klopf J, Willixhofer R, Ahmadi-Fazel D, Scheuba A, Fuchs L, Sotir A, Wanhainen A, Brostjan C, Neumayer C, Eilenberg W. MetAAA Trial Patients Receiving Metformin Therapy Show Limited Improvement in Quality of Life Compared to AAA Patients with Placebo Intake-A Double-Blind, Randomized, and Placebo-Controlled Trial. Med Sci (Basel). 2025 Nov 15;13(4):273. doi: 10.3390/medsci13040273.
• Klopf J, Willixhofer R, Scheuba A, Fuchs L, Sotir A, Wanhainen A, Brostjan C, Neumayer C, Eilenberg W. MetAAA trial patients show superior quality of life compared to patients under regular surveillance for small AAA: a single-center retrospective cohort study. Int J Surg. 2023 Apr 1;109(4):861-869. doi: 10.1097/JS9.0000000000000343.

Drugs

Indications