Intravenous and Perineural Dexamethasone for Brachial Plexus Block in Hand Surgery

Phase 0 Completed 108 enrolled Ohio State University

RandomizedParallel-groupSingle-blindPrevention

Summary

This study aims to evaluate the if the administration of dexamethasone both around the nerve and in the vein (perineural and intravenous (IV)) will prolong the duration of pain relief from ropivacaine when compared with ropivacaine local block alone or when administered along with IV dexamethasone in patients undergoing hand surgery.

Timeline

Start: 2018-10-23
Primary completion: 2024-10-20
Completion: 2024-10-20

Publications

Hussain N, Speer J, D'Souza RS, Palettas M, Abdel-Rasoul M, Uribe A, Weaver TE, Kushelev M, Coffman J, Abdallah FW. Exploring the Additive or Synergistic Effects of the Systemic and Perineural Routes of Dexamethasone as Adjuncts to Supraclavicular Block: A Randomized Controlled Trial. Anesthesiology. 2025 Jun 1;142(6):1127-1137. doi: 10.1097/ALN.0000000000005433. Epub 2025 Mar 4.
Bei T, Liu J, Huang Q, Wu J, Zhao J. Perineural Versus Intravenous Dexamethasone for Brachial Plexus Block: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Pain Physician. 2021 Sep;24(6):E693-E707.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	5 mg	Intravenous
Subject	Dexamethasone	Small molecule	10 mg	Intravenous

Indications

No indication recorded.