drugset / Trial / NCT03514836

A Phase I/II, Safety Clinical Trial of DCVAC/PCa and ONCOS-102 in Men With Metastatic Castration-resistant Prostate Cancer

NCT03514836

Phase 1/2 Terminated 5 enrolled SOTIO a.s.
NaSingle-groupOpen-labelTreatment

Summary

This clinical trial is to evaluate the safety of the combination of DCVAC/PCa with ONCOS-102 in men with castration-resistant advanced metastatic prostate cancer, who have progressed following initial therapy with either hormones (e.g. abiraterone and enzalutamide) or chemotherapy. Male patients with castration-resistant advanced metastatic prostate cancer, who have progressed following initial therapy with either All patients must have at least one readily accessible soft tissue/nodal tumor lesion (for intra-tumoral application of ONCOS-102 and biopsy.

Timeline

Start
2018-05-23
Primary completion
2021-01-25
Completion
2021-01-25

Drugs

EvaluationDrugModalityDoseRoute
Subject ONCOS-102 Unknown Other
Subject STAPULDENCEL Vaccine Subcutaneous
Background Cyclophosphamide Other / unclassified 300 mg/m2 Intravenous