Automated Postoperative Sedation After Cardiac Surgery

Summary

This study compares automated administration of propofol and remifentanil guided by the Bispectral index (BIS) versus manual administration for sedation after cardiac surgery.

Timeline

Start

2018-12-17

Primary completion

2019-03-28

Completion

2019-03-30

Outcome

Met primary endpoint

Stopped: “Modification of the device”

paper Adequate sedation (BIS(40-60)) was significantly more frequent in the automated group 77 [59-82] % than in the manual group 36 [22-56] %, with p = 0.001. PMID 23223772 ↗

Publications

• Results Liu N, Chazot T, Hamada S, Landais A, Boichut N, Dussaussoy C, Trillat B, Beydon L, Samain E, Sessler DI, Fischler M. Closed-loop coadministration of propofol and remifentanil guided by bispectral index: a randomized multicenter study. Anesth Analg. 2011 Mar;112(3):546-57. doi: 10.1213/ANE.0b013e318205680b. Epub 2011 Jan 13.
• Results Le Guen M, Liu N, Bourgeois E, Chazot T, Sessler DI, Rouby JJ, Fischler M. Automated sedation outperforms manual administration of propofol and remifentanil in critically ill patients with deep sedation: a randomized phase II trial. Intensive Care Med. 2013 Mar;39(3):454-62. doi: 10.1007/s00134-012-2762-2. Epub 2012 Dec 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	—	Intravenous
Subject	Remifentanil	Small molecule	—	Intravenous

Indications

No indication recorded.