drugset / Trial / NCT03519997

A Study of Pembrolizumab and Bavituximab in Patients With Advanced Hepatocellular Carcinoma

NCT03519997

Phase 2 Completed 35 enrolled David Hsieh Merck Sharp & Dohme LLC · collab
NaSingle-groupOpen-labelTreatment

Summary

This is a non-randomized, open-label, multi-site phase II therapeutic trial of pembrolizumab and bavituximab in patients with locally advanced HCC. Locally advanced or metastatic HCC is defined as disease that is not amenable to surgical and/or locoregional therapies. Subjects must not have received prior systemic therapy for advanced HCC in keeping with the first-line setting of this study.

Timeline

Start
2018-04-26
Primary completion
2023-04-21
Completion
2026-03-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Bavituximab Monoclonal antibody 3 mg/kg Intravenous
Subject Pembrolizumab Monoclonal antibody 200 mg Intravenous