Drugs / Bavituximab

Trials 25 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 17 trials
Phase 1 NCT01634685 Aug 2012 → Oct 2015 rectum adenocarcinoma University of Texas Southwestern Medical Center Completed No outcome recorded
Phase 1 NCT01323062 May 2011 → May 2014 non-small cell lung carcinoma UNC Lineberger Comprehensive Cancer Center Completed No outcome recorded
Phase 1 NCT01288261 Jan 2011 → May 2013 Her2-receptor negative breast cancer, male breast carcinoma University of Arizona Completed No outcome recorded
Phase 1 NCT00503347 Jul 2007 → Mar 2011 HIV infectious disease, chronic hepatitis C virus infection Peregrine Pharmaceuticals Completed No outcome recorded
Phase 1 NCT00343525 May 2006 → Jan 2007 hepatitis C virus infection Peregrine Pharmaceuticals Completed No outcome recorded
Phase 1 NCT00128271 Aug 2005 → Aug 2006 chronic hepatitis C virus infection Peregrine Pharmaceuticals Completed No outcome recorded
Phase 1 NCT00129337 Jun 2005 → Aug 2009 neoplasm Peregrine Pharmaceuticals Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT01335204 Jun 2011 → Mar 2013 prostate cancer Medical University of South Carolina Terminated No outcome recorded
Phase 1/2 NCT01264705 Jan 2011 → Apr 2018 hepatocellular carcinoma University of Texas Southwestern Medical Center Completed No outcome recorded
Phase 1/2 NCT01273948 Jan 2011 → Jan 2012 hepatitis C virus infection Peregrine Pharmaceuticals Completed No outcome recorded
Phase 213 trials
Phase 2 NCT05249569 Nov → Dec 2022 hepatocellular carcinoma University of Texas Southwestern Medical Center Terminated No outcome recorded
Phase 2 NCT04150900 Jan 2020 → Sep 2024 overdue squamous cell carcinoma University of Maryland, Baltimore Active not recruiting No outcome recorded
Phase 2 NCT04099641 Sep 2019 → Dec 2021 gastric cancer, gastroesophageal cancer OncXerna Theraputics, Inc. Completed No outcome recorded
Phase 2 NCT03519997 Apr 2018 → Apr 2023 hepatocellular carcinoma David Hsieh Completed No outcome recorded
Phase 2 NCT03139916 Sep 2017 → Aug 2022 glioblastoma Massachusetts General Hospital Completed No outcome recorded
Phase 2 NCT02685306 Mar 2016 → Apr 2017 triple-negative breast carcinoma Peregrine Pharmaceuticals Withdrawn No outcome recorded
Phase 2 NCT02673814 Feb 2016 → Apr 2017 non-small cell lung carcinoma Peregrine Pharmaceuticals Withdrawn No outcome recorded
Phase 2 NCT01272791 Jan 2011 → Feb 2013 malignant pancreatic neoplasm Peregrine Pharmaceuticals Completed No outcome recorded
Phase 2 NCT01160601 Jun 2010 → Jun 2013 non-small cell lung carcinoma Peregrine Pharmaceuticals Completed No outcome recorded
Phase 2 NCT01138163 Jun 2010 → Oct 2012 non-small cell lung carcinoma Peregrine Pharmaceuticals Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02651610 Dec 2015 → Dec 2017 breast cancer Peregrine Pharmaceuticals Withdrawn No outcome recorded
Phase 31 trial
Phase 3 NCT01999673 Dec 2013 → Mar 2017 non-small cell lung carcinoma Peregrine Pharmaceuticals Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT02989870 Background Mar 2017 → Oct 2018 hepatocellular carcinoma H. Lee Moffitt Cancer Center and Research Institute Withdrawn No outcome recorded
Phase 1 NCT01984255 Comparator Apr 2014 → Apr 2016 melanoma University of Texas Southwestern Medical Center Terminated No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 28 sources stand behind the page.

FieldValueCited text
Known as Bavituximab Bavituximab 3mg/kg IVqwk (IV every week) x 14 plus ipilimumab 3mg/kg IVq3wk (IV every 3 weeks) x 4 or ipilimumab 3mg/kg IVq3wk x 4” NCT01984255
26

NCT01323062

NCT04099641

NCT01264705

NCT01138163

NCT00129337

NCT01634685

NCT00503347

NCT00669591

NCT03519997

NCT02989870

NCT04150900

NCT00687817

NCT03139916

NCT01273948

NCT02651610

NCT01288261

NCT01335204

NCT02685306

NCT02673814

NCT00669565

NCT01272791

NCT01999673

NCT00128271

NCT00343525

NCT05249569

NCT01160601

Known as CH3G4 ChEMBL registry synonym — accepted as the source's own label CHEMBL1742989
Known as TARVACIN ChEMBL registry synonym — accepted as the source's own label CHEMBL1742989
Action Inhibit “Laboratory and animal studies have demonstrated that bavituximab specifically targets cancer cells and inhibits tumor growth in a variety of experimental cancer models.” NCT00129337
Modality Monoclonal antibody “Chimeric Anti-Phosphatidylserine Monoclonal Antibody (Bavituximab)” NCT00128271
Route Intravenous “bavituximab when administered via a vein as a single infusion” NCT00128271