Pre-emptive Analgesics in Orthodontic Treatment

Summary

This study is designed to determine if the preemptive use of a combination of acetaminophen and ibuprofen is more effective in reducing pain following orthodontic tooth movement when compared to the use of acetaminophen and ibuprofen alone.

Timeline

Start

2017-05-02

Primary completion

2017-06-23

Completion

2017-08-01

Outcome

Mixed primary results

registry Acetaminophen vs Ibuprofen vs Acetaminophen and Ibuprofen; p = 0.04; ANOVA NCT03523988 ↗

registry MEAN Acetaminophen: Rest: 0.6 (Standard Deviation 0.8) scores on a scale NCT03523988 ↗

registry MEAN Ibuprofen: Rest: 2.6 (Standard Deviation 2.2) scores on a scale NCT03523988 ↗

registry Acetaminophen vs Ibuprofen vs Acetaminophen and Ibuprofen; p = 0.63; ANOVA NCT03523988 ↗

registry Acetaminophen vs Ibuprofen vs Acetaminophen and Ibuprofen; p = 0.65; ANOVA NCT03523988 ↗

registry Acetaminophen vs Ibuprofen vs Acetaminophen and Ibuprofen; p = 0.53; ANOVA NCT03523988 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetaminophen	Small molecule	650 mg	Oral
Subject	Ibuprofen	Small molecule	400 mg	Oral

Indications

No indication recorded.