drugset

drugset / Trial / NCT03555188

TReatment of Irritable Bowel Syndrome With Diarrhoea Using Titrated ONdansetron Trial

NCT03555188 ↗

Phase 3 Completed 80 enrolled University of Leeds Barnsley Hospital NHS Foundation Trust · collab Barts & The London NHS Trust · collab County Durham and Darlington NHS Foundation Trust · collab Flinders University · collab London North West Healthcare NHS Trust · collab Manchester University NHS Foundation Trust · collab NHS Lothian · collab National Institute for Health Research, United Kingdom · collab Queen Mary University of London · collab Sandwell & West Birmingham Hospitals NHS Trust · collab Sheffield Teaching Hospitals NHS Foundation Trust · collab The Leeds Teaching Hospitals NHS Trust · collab University College London Hospitals · collab University Hospitals of North Midlands NHS Trust · collab University of Manchester · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

A placebo controlled study to determine the efficacy and mode of action of ondansetron in the treatment of irritable bowel syndrome with diarrhoea.

Timeline

Start: 2018-03-29
Primary completion: 2020-08-03
Completion: 2020-09-10

Publications

Results Gunn D, Topan R, Barnard L, Fried R, Holloway I, Brindle R, Corsetti M, Scott M, Farmer A, Kapur K, Sanders D, Eugenicos M, Trudgill N, Whorwell P, Mclaughlin J, Akbar A, Houghton L, Dinning PG, Aziz Q, Ford AC, Farrin AJ, Spiller R. Randomised, placebo-controlled trial and meta-analysis show benefit of ondansetron for irritable bowel syndrome with diarrhoea: The TRITON trial. Aliment Pharmacol Ther. 2023 Jun;57(11):1258-1271. doi: 10.1111/apt.17426. Epub 2023 Mar 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ondansetron	Other / unclassified	8 mg	Oral

Indications