The Optimal Dose of Sevoflurane Via Anaconda® in Post-operative Patient Underwent Head & Neck Surgery
Summary
Sedation in the ICUs is very common. There is no ideal sedative yet, so research has been conducted to replace propofol and midazolam, which are the most commonly used sedatives in ICUs, by inhalation anesthetics. The investigators will sedate the patients who undergo head \& neck surgery with tracheostomy for several days using sevoflurane, a kind of inhalation agent, via anesthetic conserving device. The objective of this study is to confirm the end-tidal sevoflurane concentration for inducing moderate sedation (RASS -2\~-3). In addition, the investigators compare the volatile sedation with the IV(intravenous) sedation to see if the volatile sedation could reduce the amount of post-operative opioid consumption. * RASS: Richmond Agitation-Sedation Scale * RASS: Richmond Agitation-Sedation Scale
Timeline
- Start
- 2018-04-03
- Primary completion
- 2019-03-31
- Completion
- 2019-03-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | — | Intravenous |
| Subject | Sevoflurane | Other / unclassified | 0.4 % | Inhaled |
| Subject | Sevoflurane | Other / unclassified | 0.5 % | Inhaled |
| Subject | Sevoflurane | Other / unclassified | 0.6 % | Inhaled |
Indications
No indication recorded.