drugset

drugset / Trial / NCT03571802

Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)

NCT03571802 ↗

Phase 4 Unknown 10 enrolled National University Hospital, Singapore

NaSingle-groupOpen-labelTreatment

Summary

This study aims to investigate the change in systemic exposure of simvastatin post LSG.

Timeline

Start: 2018-06-13
Primary completion: 2025-06-30
Completion: 2025-06-30

Publications

Background Skottheim IB, Stormark K, Christensen H, Jakobsen GS, Hjelmesaeth J, Jenssen T, Reubsaet JL, Sandbu R, Asberg A. Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients. Clin Pharmacol Ther. 2009 Sep;86(3):311-8. doi: 10.1038/clpt.2009.82. Epub 2009 Jun 3.
Background Jakobsen GS, Skottheim IB, Sandbu R, Christensen H, Roislien J, Asberg A, Hjelmesaeth J. Long-term effects of gastric bypass and duodenal switch on systemic exposure of atorvastatin. Surg Endosc. 2013 Jun;27(6):2094-101. doi: 10.1007/s00464-012-2716-3. Epub 2012 Dec 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Simvastatin	Small molecule	20 mg	Oral

Indications