drugset / Trial / NCT03576053
A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing
RandomizedCrossoverDouble-blindBasic science
Summary
The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch. Moreover, the purpose is to evaluate the effect of mild pre-heating of the skin in human experimental models of histamine, cowhage and serotonin. Finally, we want to investigate the effect of short-term intense heat stimulation on previously anesthetized skin.
Timeline
- Start
- 2018-07-01
- Primary completion
- 2019-07-31
- Completion
- 2019-08-28
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Lidocaine | Other / unclassified | — | Other |
Indications
No indication recorded.