A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin

Summary

The aim of this project is to study the role of transient receptor potential (TRP-) channel V1 (TRPV1+) fibers in the development of cutaneous inflammation induced by epidermal Ultraviolet-B damage. Moreover, in this project the investigators want to evaluate if the capsaicin-desensitization action can still be induced in a skin area pretreated with topical, local anesthetic lidocaine.

Timeline

Start

2018-08-01

Primary completion

2019-08-31

Completion

2019-12-31

Drugs

Indications