Liposomal Bupivacaine Interscalene Blocks for Rotator Cuff Repair

Phase 4 Completed 80 enrolled University of Minnesota

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to compare pain control after arthroscopic rotator cuff repair surgery using either liposomal bupivacaine or bupivacaine when injected in an interscalene block. Both medications, liposomal bupivacaine and bupivacaine, are standard of care in these types of surgeries.

Timeline

Start: 2018-07-25
Primary completion: 2021-05-25
Completion: 2021-06-08

Outcome

Missed primary endpoint

paper LB added to bupivacaine interscalene blocks does not reduce opioid consumption within 72 hours following arthroscopic RCR. PMID 35190468 ↗

Publications

Flaherty JM, Berg AA, Harrison A, Braman J, Pearson JM, Matelich B, Kaizer AM, Hutchins JL. Comparing liposomal bupivacaine plus bupivacaine to bupivacaine alone in interscalene blocks for rotator cuff repair surgery: a randomized clinical trial. Reg Anesth Pain Med. 2022 May;47(5):309-312. doi: 10.1136/rapm-2021-103349. Epub 2022 Feb 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	10 ml	Other
Subject	Bupivacaine	Other / unclassified	20 ml	Other
Subject	Bupivacaine	Other / unclassified	133 mg	Other

Indications

No indication recorded.