Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS)

Summary

Phase 3, open-label, multi-center trial to evaluate the long-term safety, efficacy, and immunogenicity of up to four continuous treatment cycles of daxibotulinumtoxinA (DAXI) for injection.

Timeline

Start

2018-09-05

Primary completion

2021-05-25

Completion

2021-05-25

Publications

• McAllister P, Patel AT, Banach M, Ellenbogen A, Slawek J, Paus S, Jinnah HA, Evidente V, Gross TM, Kazerooni R, Gallagher CJ, Hollander DA. Long-Term Safety and Efficacy of Repeat Treatments with DaxibotulinumtoxinA in Cervical Dystonia: Results from the ASPEN-Open-Label Study. Mov Disord Clin Pract. 2025 Nov;12(11):1764-1773. doi: 10.1002/mdc3.70104. Epub 2025 May 29.

Drugs

Indications