Effectiveness Fluoride Varnishes in Children With Early Childhood Caries
Summary
The study was carried out in 88 children with severe early childhood caries (dmfs≥age +1) who were referred to the investigators' clinic. Patients who completed dental treatment under general anesthesia in a single session, were included to the study. Patients were divided randomly into 4 groups and after dental treatment one of the fluoride varnish listed below was applied to each child. The groups were as follows; 1. Duraphat varnish containing 5% Sodium Fluoride (Colgate) (n = 22), 2. Clinpro ™ White Varnish containing 5% of Sodium Fluoride tricalcium phosphate (3M ESPE) (n = 22), 3. Embrace ™ Varnish containing 5% Sodium Fluoride with CXP ™ (Pulpdent) (n = 22), 4. MI Varnish containing 5% Sodium Fluoride casein phosphopeptide amorphous calcium phosphate varnish (GC) (n = 22). Saliva Mutans streptococci (MS) and Lactobacilli (LB) levels, were evaluated by taking saliva samples before general anaesthesia; one month after treatment and three months after treatment.
Timeline
- Start
- 2016-11
- Primary completion
- 2017-07
- Completion
- 2017-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Fluoride varnish | Other / unclassified | 5 % | Topical |
| Subject | Sodium Fluoride with CXP | Unknown | 5 % | Topical |
| Subject | Sodium Fluoride with TCP | Unknown | 5 % | Topical |
| Comparator | sodium fluoride | Unknown | 5 % | Topical |