drugset / Trial / NCT03628716
CV301 Combined With PD-1/L1 Blockade in Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer
NaSingle-groupOpen-labelTreatment
Summary
This is a Phase 2, single-arm, multi-institutional clinical trial designed to study the combination of CV301 with atezolizumab in the first-line treatment of UC not eligible for cisplatin-containing chemotherapy (Cohort 1) and in the second-line treatment of UC previously treated with standard first-line cisplatin-based chemotherapy (Cohort 2).
Timeline
- Start
- 2018-09-18
- Primary completion
- 2020-11-03
- Completion
- 2021-02-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Atezolizumab | Monoclonal antibody | 1200 mg | Intravenous |
| Subject | FPV-CV301 | Vaccine | 1e+09 unknown | Subcutaneous |
| Subject | MVA-BN-CV301 | Vaccine | 1.6e+09 unknown | Subcutaneous |