drugset / Trial / NCT03628716

CV301 Combined With PD-1/L1 Blockade in Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer

NCT03628716

Phase 2 Completed 43 enrolled Bavarian Nordic
NaSingle-groupOpen-labelTreatment

Summary

This is a Phase 2, single-arm, multi-institutional clinical trial designed to study the combination of CV301 with atezolizumab in the first-line treatment of UC not eligible for cisplatin-containing chemotherapy (Cohort 1) and in the second-line treatment of UC previously treated with standard first-line cisplatin-based chemotherapy (Cohort 2).

Timeline

Start
2018-09-18
Primary completion
2020-11-03
Completion
2021-02-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Atezolizumab Monoclonal antibody 1200 mg Intravenous
Subject FPV-CV301 Vaccine 1e+09 unknown Subcutaneous
Subject MVA-BN-CV301 Vaccine 1.6e+09 unknown Subcutaneous