The Effect of Paracetamol on Brain Temperature

Summary

The main objective of this study is to compare the effect of intravenous paracetamol administration on mean brain temperature (measured between H0 and H6) in patients with cerebral hyperthermia versus placebo. The investigators will measure brain temperature using a thermistor that will be connected to the intracranial pressure transducer.

Timeline

Start

2018-05-03

Primary completion

2022-05-26

Completion

2022-05-26

Publications

• de Mesmay M, Geral L, Gregoire C, Roy M, Welschbillig S, Le Cossec C, Engrand N. Effect of Paracetamol on Cerebral Temperature in Febrile Brain-Injured Patients. The NEUROTHERM Study: A Randomized Controlled Pharmacodynamic Trial. Crit Care Med. 2026 Jan 1;54(1):108-118. doi: 10.1097/CCM.0000000000006951. Epub 2025 Nov 11.

Drugs

Indications