Dose-response of Cannabis and Driving

Summary

Epidemiological studies have established a link between collisions while driving and cannabis use. With the changing legal landscape around cannabis, there is much interest in determining per se limits of cannabis while driving. The present study will evaluate driving on a driving simulator after smoking placebo or cannabis with 3 different levels of THC. THC is the active component in cannabis and blood, urine and oral fluid levels of THC will be correlated with driving impairment.

Timeline

Start

2021-06-04

Primary completion

2022-06-14

Completion

2022-06-14

Publications

• Brands B, Zaweel A, Wright M, Di Ciano P, Wickens CM, Matheson J, Fares A, Hasan OSM, Sanches M, Sproule B, Huestis MA, Brown TL, Le Foll B. Potency-related effects of smoked cannabis on simulated driving performance: a randomized, controlled crossover trial. Sci Rep. 2026 Mar 10;16(1):12961. doi: 10.1038/s41598-026-43045-2.

Drugs

Indications