Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disease

Summary

To compare changes in Left Ventricular Mass (LVM) depending on each blood pressure regulation between the intensive care group and the usual care group for patients with hypertension accompanied by aortic valve disease and evaluate an influence of blood pressure regulation on improvement of left ventricular hypertrophy and its safety

Timeline

Start

2018-10-18

Primary completion

2022-07-25

Completion

2022-07-25

Outcome

Met primary endpoint

paper The primary end point of change in LV mass was significantly different between the intensive therapy and the standard therapy group PMID 38006908 ↗

paper (-3.9 ± 20.2 g vs 10.3 ± 20.4 g; P = .0007). PMID 38006908 ↗

paper intensive hypertensive therapy resulted in a significant reduction in LV hypertrophy PMID 38006908 ↗

Publications

• Kim M, Choi JH, Kim HK, Kim HL, Shin SH, Jang JY, Park JH, Kim KH, Hong GR, Park SM, Lee SA, Kang DH. Effects of intensive blood pressure control on left ventricular hypertrophy in aortic valve disease. Am Heart J. 2024 Feb;268:45-52. doi: 10.1016/j.ahj.2023.11.012. Epub 2023 Nov 23.
• Saiz LC, Gorricho J, Garjon J, Celaya MC, Erviti J, Leache L. Blood pressure targets for the treatment of people with hypertension and cardiovascular disease. Cochrane Database Syst Rev. 2022 Nov 18;11(11):CD010315. doi: 10.1002/14651858.CD010315.pub5.
• Saiz LC, Gorricho J, Garjon J, Celaya MC, Erviti J, Leache L. Blood pressure targets for the treatment of people with hypertension and cardiovascular disease. Cochrane Database Syst Rev. 2020 Sep 9;9(9):CD010315. doi: 10.1002/14651858.CD010315.pub4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Amlodipine	Other / unclassified	5 mg	—
Subject	Chlorthalidone	Other / unclassified	12.5 mg	—
Subject	Losartan	Other / unclassified	50 mg	—
Subject	Losartan	Other / unclassified	100 mg	—

Indications