Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy

Summary

The investigators will assess how the use of toradol and pregabalin affects return to bowel function and see if there is a difference in length of hospital stay. Narcotic use can affect bowel function so the investigators hypothesize that use of Toradol will decrease delayed bowel function and aid in a patients discharge and reduction of hospital stay.

Timeline

Start

2016-09-20

Primary completion

2018-09-30

Completion

2018-09-30

Outcome

Met primary endpoint

registry MEDIAN Toradol and Lyrica: 27 (13 to 42.3) mg NCT03669081 ↗

registry analysis (other test); Toradol and Lyrica vs Placebo and Standard of Care; p = 0.006; Wilcoxon (Mann-Whitney); note: The significance level for this test was 0.05. NCT03669081 ↗

registry analysis (other test); Toradol and Lyrica vs Placebo and Standard of Care; p = 0.029; Exact Wilcoxon rank sum test NCT03669081 ↗

Publications

• Campsen J, Call T, Allen CM, Presson AP, Martinez E, Rofaiel G, Kim RD. Prospective, double-blind, randomized clinical trial comparing an ERAS pathway with ketorolac and pregabalin versus standard of care plus placebo during live donor nephrectomy for kidney transplant. Am J Transplant. 2019 Jun;19(6):1777-1781. doi: 10.1111/ajt.15242. Epub 2019 Jan 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketorolac	Other / unclassified	15 mg	Intravenous
Subject	Pregabalin	Small molecule	75 mg	Oral

Indications