Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy

Summary

This phase II trial studies how well megestrol acetate with or without pterostilbene works in treating patients with endometrial cancer undergoing hysterectomy. Drugs used in chemotherapy, such as megestrol acetate, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Pterostilbene is an antioxidant found in blueberries or grapes, and it has been shown to be effective in killing tumor cells and reducing cancer burden. It is not yet known whether giving megestrol acetate with or without pterostilbene may work better in treating patients with endometrial cancer.

Timeline

Start

2019-01-21

Primary completion

2022-12-12

Completion

2027-02-28

Outcome

Missed primary endpoint

registry analysis (superiority test); Arm I (Pterostilbene, Megestrol Acetate) vs Arm II (Megestrol Acetate); p = 0.9; t-test, 1 sided NCT03671811 ↗

Drugs

Indications