Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery

Phase 4 Completed 125 enrolled The Institute of Molecular and Translational Medicine, Czech Republic General University Hospital, Prague · collab Hospital Novy Jicin · collab Tomas Bata Hospital, Czech Republic · collab University Hospital Ostrava · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery. To find correlations with other perioperative factors and clinical/pathological disease characteristics.

Timeline

Start: 2019-01-07
Primary completion: 2023-11-01
Completion: 2023-12-06

Publications

Berta E, Srovnal J, Dytrych P, Bruthans J, Ulrichova J, Prasil P, Vecera L, Gabrhelik T, Tolmaci B, Dusa J, Maca J, Mazancova M, Haiduk F, Kutej M, Ihnat P, Michalek P, Hajduch M. Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial. BMC Anesthesiol. 2023 Feb 28;23(1):64. doi: 10.1186/s12871-023-02007-1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Morphine	Other / unclassified	—	Intravenous
Comparator	Piritramide	Small molecule	—	Intravenous

Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery

Summary

Timeline

Publications

Drugs

Indications