Comparing Local Anesthetics for TAP Block During Abdominally-based Free Flap for Breast Reconstruction

Phase 4 Completed 60 enrolled Vanderbilt University Medical Center

RandomizedParallel-groupDouble-blindTreatment

Summary

This study will compare the efficiency of transversus abominus plane (TAP) block using liposomal bupivacaine versus plain bupivacaine that is administered in the operating room under ultrasound guidance prior to the in patients undergoing abdominally-based free flap breast reconstruction at Vanderbilt University Medical Center.

Timeline

Start: 2019-06-13
Primary completion: 2021-03-15
Completion: 2021-03-30

Publications

Nguyen L, Glassman GE, Afshari A, Feng X, Shastri UD, Kaoutzanis C, McEvoy MD, Bansal V, Canlas C, Yao J, Higdon K, Perdikis G. Randomized Controlled Trial Comparing Liposomal to Plain Bupivacaine in the Transversus Abdominis Plane for DIEP Flap Breast Reconstruction. Plast Reconstr Surg. 2024 Mar 1;153(3):543-551. doi: 10.1097/PRS.0000000000010710. Epub 2023 May 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	1.3 %	Other
Subject	Bupivacaine	Other / unclassified	20 ml	Other
Comparator	Regular bupivacaine	Unknown	0.25 %	Other
Comparator	Regular bupivacaine	Unknown	20 ml	Other

Indications

No indication recorded.