drugset / Trial / NCT03706755

Comparison of Two Doses of Norepinephrine in Preventing Hypotension After Spinal Anesthesia

NCT03706755

Phase 4 Completed 124 enrolled University Tunis El Manar
RandomizedParallel-groupTriple-blindPrevention

Summary

The purpose of the study is to determine the more effective intravenous bolus of norepinephrine for maintaining blood pressure during a spinal anesthesia for a cesarean delivery with the fewer side effects. Low blood pressure has been shown to decrease uterine perfusion and foetal outcomes during cesarean delivery under spinal anesthesia. For elective or semi-urgent cesarean delivery, all participants will receive spinal anesthesia with a local anesthetic and either sufentanil or fentanyl. This study plans to enroll 124 pregnant women. Patients will be randomly assigned according to a computer generated system to be in one of two groups.

Timeline

Start
2018-05-03
Primary completion
2018-09-02
Completion
2018-10-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Norepinephrine Other / unclassified 0.5 ug/kg Intravenous
Comparator Norepinephrine Other / unclassified 1 ug/kg Intravenous

Indications