Bivalirudin vs Heparin in ECMO Patients

Phase 1 Withdrawn Johns Hopkins University

RandomizedParallel-groupOpen-labelTreatment

Summary

This is an open label, randomized study comparing the clinical outcomes of unfractionated Heparin and Bivalirudin for anticoagulation in adult subjects requiring ECMO support.

Timeline

Start: 2021-04
Primary completion: 2021-06
Completion: 2021-06

Publications

Hasegawa D, Sato R, Prasitlumkum N, Nishida K, Keaton B, Acquah SO, Im Lee Y. Comparison of Bivalirudin Versus Heparin for Anticoagulation During Extracorporeal Membrane Oxygenation. ASAIO J. 2023 Apr 1;69(4):396-401. doi: 10.1097/MAT.0000000000001814. Epub 2022 Apr 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bivalirudin	Peptide	—	Intravenous
Comparator	Heparin	Other / unclassified	—	Intravenous

Indications

No indication recorded.