drugset / Trial / NCT03712904
Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma
Phase 2
Terminated
3 enrolled
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Regeneron Pharmaceuticals · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This phase II trial studies how well stereotactic body radiation therapy and aflibercept work in treating patients with uveal melanoma. Stereotactic body radiation therapy is a specialized radiation therapy that sends x-rays directly to the tumor using smaller doses over several days and may cause less damage to normal tissue. Aflibercept may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving stereotactic body radiation therapy followed by aflibercept may work better in treating patients with uveal melanoma.
Timeline
- Start
- 2019-08-09
- Primary completion
- 2022-09-20
- Completion
- 2022-12-23
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aflibercept | Protein / enzyme biologic | — | Intravenous |