The Effect of Tranexamic Acid. A Randomised Study of Patients Undergoing Elective Lumbar Spine Surgery.

Phase 4 Completed 250 enrolled Mikkel Østerheden Andersen

RandomizedParallel-groupTriple-blindTreatment

Summary

In this randomized double blind placebo controlled study of tranexamic acid during minor spinal surgery, mean postoperative blood loss in the patients who received TXA was statistically significantly lower compared to placebo.

Timeline

Start: 2015-10-19
Primary completion: 2016-08-16
Completion: 2016-08-16

Outcome

Missed primary endpoint

paper Tranexamic acid did not have a statistically significant effect on operative time, intraoperative blood loss, or complications. PMID 30978683 ↗

Publications

Elmose S, Andersen MO, Andresen EB, Carreon LY. Double-blind, randomized controlled trial of tranexamic acid in minor lumbar spine surgery: no effect on operative time, intraoperative blood loss, or complications. J Neurosurg Spine. 2019 Apr 12;31(2):194-200. doi: 10.3171/2019.1.SPINE1814. Print 2019 Aug 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tranexamic Acid	Small molecule	10 mg/kg	Intravenous

Indications

No indication recorded.