Using Intranasal Midazolam (INM) and Lidocaine for Uncooperative Children

Summary

Aims: The objective of the current study was to evaluate the effectiveness of topical lidocaine in relieving pain related to INM administration. Design: This was a blinded, randomized placebo-controlled trial. Sixty-three uncooperative children, aged 4 - 11.

Timeline

Start

2017-06-01

Primary completion

2018-01-01

Completion

2018-10-10

Outcome

Met primary endpoint

paper less discomfort with IN midazolam administration (median WBS = 3, interquartile range [IQR] = 0-6) than those who received placebo PMID 27739142 ↗

paper than those who received placebo (median WBS = 8, IQR = 2-9; p = 0.006). PMID 27739142 ↗

Publications

• Results Smith D, Cheek H, Denson B, Pruitt CM. Lidocaine Pretreatment Reduces the Discomfort of Intranasal Midazolam Administration: A Randomized, Double-blind, Placebo-controlled Trial. Acad Emerg Med. 2017 Feb;24(2):161-167. doi: 10.1111/acem.13115. Epub 2017 Jan 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	2 %	Intranasal
Background	Midazolam	Small molecule	0.5 mg/kg	Intranasal

Indications

No indication recorded.