Using Intranasal Midazolam (INM) and Lidocaine for Uncooperative Children

Phase 2/3 Completed 63 enrolled Latakia University

RandomizedParallel-groupDouble-blindTreatment

Summary

Aims: The objective of the current study was to evaluate the effectiveness of topical lidocaine in relieving pain related to INM administration. Design: This was a blinded, randomized placebo-controlled trial. Sixty-three uncooperative children, aged 4 - 11.

Timeline

Start: 2017-06-01
Primary completion: 2018-01-01
Completion: 2018-10-10

Publications

Results Smith D, Cheek H, Denson B, Pruitt CM. Lidocaine Pretreatment Reduces the Discomfort of Intranasal Midazolam Administration: A Randomized, Double-blind, Placebo-controlled Trial. Acad Emerg Med. 2017 Feb;24(2):161-167. doi: 10.1111/acem.13115. Epub 2017 Jan 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	2 %	Intranasal
Background	Midazolam	Small molecule	0.5 mg/kg	Intranasal

Indications

No indication recorded.