High-Dose Steroid for Knee Arthroplasty Patients Expected to Have Postoperative Pain

Phase 4 Completed 88 enrolled Copenhagen University Hospital, Hvidovre Sygehus Lillebaelt · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of the Study is to test a higher dose of steroids(Dexamethasone) given just prior to surgery in the setting of Fast-Track Knee surgery with Arthroplasty in a group of expected High Pain Responders and the effect on postoperative pain and postoperative inflammation.

Timeline

Start: 2019-01-29
Primary completion: 2021-01-01
Completion: 2021-01-01

Outcome

Met primary endpoint

paper Moderate-to-severe pain when walking 24 h postoperatively was reduced (high dose vs intermediate dose, 49% vs 79%; P<0.01) PMID 34749994 ↗

Publications

Nielsen NI, Kehlet H, Gromov K, Troelsen A, Husted H, Varnum C, Kjaersgaard-Andersen P, Rasmussen LE, Pleckaitiene L, Foss NB. High-dose steroids in high pain responders undergoing total knee arthroplasty: a randomised double-blind trial. Br J Anaesth. 2022 Jan;128(1):150-158. doi: 10.1016/j.bja.2021.10.001. Epub 2021 Nov 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	0.3 mg/kg	Intravenous
Subject	Dexamethasone	Small molecule	1 mg/kg	Intravenous