drugset

drugset / Trial / NCT03765359

Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes.

NCT03765359 ↗

Phase 4 Completed 101 enrolled Tampere University Hospital Central Finland Hospital District · collab Helsinki University Central Hospital · collab Oulu University Hospital · collab Turku University Hospital · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The study investigates whether additional metformin medication in combination with regular insulin treatment will decrease the need of insulin for women with diabetes mellitus type 1 during pregnancy.

Timeline

Start: 2019-08-05
Primary completion: 2022-12-19
Completion: 2022-12-19

Publications

Juuma E, Tihtonen K, Metso SE, Hannula PM, Helminen M, Tertti K, Immonen H, Georgiadis L, Vayrynen K, Ahtiainen P, Nikkinen H, Koivikko M, Laivuori H, Uotila J. The Effect of Metformin on Insulin Requirement, Glycaemic Control and Weight Gain in Type 1 Diabetes During Pregnancy-a Randomised, Placebo-Controlled Multicentre Study. Diabetes Metab Res Rev. 2025 Sep;41(6):e70085. doi: 10.1002/dmrr.70085.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Metformin	Small molecule	2000 mg	—

Indications