Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.

Summary

Endothelial damage has been reported after ischemia-reperfusion events. This can be characterized by measurements of glycocalyx and endothelial components that are released to blood after the insult. Sevoflurane and inhaled anesthetic commonly used for surgery have shown protective endothelial effects in animal and in-vitro models. Knee-ligament surgery with the use of a femoral tourniquet generates a transient ischemia-reperfusion (IR) state after the tourniquet is released. This research aims to compare the effect of sevoflurane and propofol in the release of glycocalyx and endothelial biomarkers after IR in this surgical scenario.

Timeline

Start

2018-12-20

Primary completion

2019-12-11

Completion

2019-12-11

Outcome

Missed primary endpoint

paper For our primary outcome, a two-way ANOVA with post-hoc Bonferroni correction analysis showed no differences PMID 32434495 ↗

Publications

• Maldonado F, Morales D, Gutierrez R, Barahona M, Cerda O, Caceres M. Effect of sevoflurane and propofol on tourniquet-induced endothelial damage: a pilot randomized controlled trial for knee-ligament surgery. BMC Anesthesiol. 2020 May 20;20(1):121. doi: 10.1186/s12871-020-01030-w.

Drugs

Indications