ED90 for Hyperbaric Bupivacaine in Super Obese Parturients

Phase 4 Completed 45 enrolled Duke University

Non-randomizedSequentialTriple-blindTreatment

Summary

The aim of this study is to determine the ED90 of hyperbaric intrathecal bupivacaine for the super obese population undergoing cesarean section under a combined spinal epidural technique.

Timeline

Start: 2019-05-01
Primary completion: 2022-12-06
Completion: 2022-12-06

Publications

Tan HS, Fuller ME, Barney EZ, Diomede OI, Landreth RA, Pham T, Rubright SM, Ernst L, Habib AS. The 90% effective dose of intrathecal hyperbaric bupivacaine for Cesarean delivery under combined spinal-epidural anesthesia in parturients with super obesity: an up-down sequential allocation study. Can J Anaesth. 2024 May;71(5):570-578. doi: 10.1007/s12630-024-02705-5. Epub 2024 Mar 4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	9.75 mg	Intrathecal
Subject	Bupivacaine	Other / unclassified	10.5 mg	Intrathecal
Subject	Bupivacaine	Other / unclassified	11.25 mg	Intrathecal
Subject	Bupivacaine	Other / unclassified	12 mg	Intrathecal

ED90 for Hyperbaric Bupivacaine in Super Obese Parturients

Summary

Timeline

Publications

Drugs

Indications