Application of Vitamin E on Anal Fissure

Phase 3 Completed 160 enrolled Hospital General Universitario Elche

RandomizedParallel-groupSingle-blindTreatment

Summary

Patients were randomized into 2 groups: * Vitamin E: Vitamin E ointment will be applied during 8 weeks * Nitroglycerin: Nitroglycerin ointment will be applied during 8 weeks Healing rate of chronic anal fissure in patients receiving Nitroglycerin ointment and subjects patients receiving Vitamin E ointment were evaluated .

Timeline

Start: 2018-12-21
Primary completion: 2019-02-28
Completion: 2019-02-28

Publications

Ruiz-Tovar J, Llavero C. Perianal Application of Glyceryl Trinitrate Ointment Versus Tocopherol Acetate Ointment in the Treatment of Chronic Anal Fissure: A Randomized Clinical Trial. Dis Colon Rectum. 2022 Mar 1;65(3):406-412. doi: 10.1097/DCR.0000000000002120.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Nitroglycerin	Unknown	1.5 mg	Topical
Subject	alpha-tocopherol	Unknown	1 ml	Topical

Indications

No indication recorded.