Drugs / alpha-tocopherol
alpha-tocopherol
also known as
Vitamin E · Vitamin E acetate · a-tocopherol · RRR-alpha-tocopherol acetate · RRR-AT · VEA · Vitamine E Acetate
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | INFUVITE ADULT | — | 2000-05-18 | fda.gov ↗ |
Trials 10
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT07194304 | May 2022 → Jan 2024 | tetralogy of fallot | Dr Cipto Mangunkusumo General Hospital | Completed | No outcome recorded |
| Phase 11 trial | ||||||
| Phase 1 | NCT00862433 | Oct 2014 → Oct 2016 | fatty liver disease, obesity disorder, type 2 diabetes mellitus | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Completed | No outcome recorded |
| Phase 25 trials · 1 missed | ||||||
| Phase 2 | NCT07610304 | Jun → Aug 2022 | hyperlipidemia | NUR International University | Completed | No outcome recorded |
| Phase 2 | NCT02793648 | Oct 2014 → Nov 2017 | depressive disorder | Yolanda de Diego Otero | Completed | No outcome recorded |
| Phase 2 | NCT00188669 | Jul 2002 → ? | breast neoplasm | University Health Network, Toronto | Terminated | No outcome recorded |
| Phase 2 | NCT00000541 | May 1993 → Jul 2005 | coronary atherosclerosis, myocardial infarction, myocardial ischemia | Brigham and Women's Hospital | Completed | Missed primary |
| Phase 2 | NCT00010699 | ? → Apr 2003 | cardiovascular disorder | National Center for Complementary and Integrative Health (NCCIH) | Completed | No outcome recorded |
| Phase 33 trials · 2 met primary | ||||||
| Phase 3 | NCT03787030 | Dec 2018 → Feb 2019 | — | Hospital General Universitario Elche | Completed | Met primary |
| Phase 3 | NCT03765827 | Dec 2018 → Apr 2019 | — | Hospital General Universitario Elche | Completed | Met primary |
| Phase 3 | NCT00339768 | Jul 1995 → Jun 1996 | preneoplastic lesion | National Cancer Institute (NCI) | Completed | Mixed |
| Comparator or background therapy4 trials | ||||||
| Phase 3 | NCT01061320 Comparator | Jan → Oct 2010 | acute tubulointerstitial nephritis | Thammasat University | Unknown | No outcome recorded |
| Phase 3 | NCT01594346 Comparator | Sep 2000 → Apr 2010 | Alzheimer disease, Down syndrome | New York State Institute for Basic Research | Completed | No outcome recorded |
| Phase 3 | NCT01422317 Background | Sep 1995 → Dec 1997 | coronary artery disorder, myocardial infarction | Helse Stavanger HF | Completed | No outcome recorded |
| — | NCT03948737 Comparator | Dec 2016 → Jul 2017 | beta-thalassemia major, hemolytic anemia | Indonesia University | Completed | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 14 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | alpha-tocopherol | “The primary aim of the present study is to test the effect of alpha-tocopherol supplementation on the progression of carotid atherosclerosis in patients with coronary artery disease” NCT00010699 ↗12“Vitamin E (alpha-tocopherol) is essential for humans but determining human dietary requirements has proved difficult.” NCT00862433 ↗ “daily supplementation with a combination of alpha-tocopherol, vitamin C, and selenium” NCT00339768 ↗ “vitamin E (RRR-alpha-tocopherol acetate, 600 IU every other day)” PMID 19491386 ↗ Jun 2009 |
| Known as | a-tocopherol | “a-tocopherol (AT), the predominant lipid-soluble antioxidant in LDL” NCT00010699 ↗ |
| Known as | RRR-alpha-tocopherol acetate | “vitamin E (RRR-alpha-tocopherol acetate, 600 IU every other day)” PMID 19491386 ↗ Jun 2009 |
| Known as | RRR-AT | “The primary aim of the present study is to test the effect of AT supplementation (1200 IU/day of RRR-AT) in a placebo-controlled, randomized double blind trial” NCT00010699 ↗ |
| Known as | VEA | “Vitamin E acetate ointment (VEA): Commercially available plastic tubes containing VitaminE acetate ointment (Filme Olio, Hulka SRL, Italy) were purchased from pharmacies.” NCT03787030 ↗ |
| Known as | Vitamin E | “Vitamin E (alpha tocopherol)was demonstrated to be anti-oxidant and anti-inflammation.” NCT01061320 ↗1“vitamin E (RRR-alpha-tocopherol acetate, 600 IU every other day)” PMID 19491386 ↗ Jun 2009 |
| Known as | Vitamin E acetate | “Vitamin E acetate ointment will be applied over staple lines and anastomoses in Roux-en-Y gastric bypass.” NCT03765827 ↗ |
| Known as | Vitamine E Acetate | “Drug: Vitamine E Acetate” NCT03765827 ↗ |
| Route | Intravenous | “intravenous deuterated vitamin E” NCT00862433 ↗ |