The Use of Pentoxifylline and Vitamin E in the Treatment of Chronic Breast Pain

Summary

An estimated 20 - 45 % of women treated with breast conserving treatment experience chronic pain in the treated breast. The aetiology of this is poorly understood. Some of these women have signs of chronic radiation mastitis. There is no accepted treatment for this condition. The combination of pentoxifylline and vitamin E has been shown to be effective in reversing radiation fibrosis in this region. Many of these patients have had a benefit in pain response in a time period of a few benefits. This study is a phase II study of these drugs for a 6 month trial period to assess the effect on chronic breast pain in breast cancer patients who are 3 months to 3 years post radiation treatment.

Timeline

Start

2002-07

Primary completion

—

Completion

—

Outcome

Outcome not reported

Stopped: “date: August 2006. No annual renewal”

Drugs

Indications