drugset / Trial / NCT03787082
Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension
Phase 1
Withdrawn
Gladwin, Mark, MD
National Heart, Lung, and Blood Institute (NHLBI) · collabNational Institutes of Health (NIH) · collabUniversity of Pittsburgh · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in volunteers with PH in the breakdown of oral nitrate and effect on hemodynamics.
Timeline
- Start
- 2022-12
- Primary completion
- 2023-12
- Completion
- 2023-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 14N Nitrate | Unknown | 1000 mg | Oral |
| Subject | Chlorhexidine gluconate | Other / unclassified | 0.12 % | — |
| Subject | Chlorhexidine gluconate | Other / unclassified | 15 ml | — |