Lung Deposition of TRIMBOW® pMDI in Healthy Volunteers, Asthmatic and COPD Patients

Phase 1 Terminated 19 enrolled Chiesi Farmaceutici S.p.A.

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to investigate the lung deposition and distribution pattern of TRIMBOW using a Gamma-scintigraphic technique after inhalation of a single dose of 99mTc radiolabelled TRIMBOW administered via pMDI in healthy volunteers, asthmatic and COPD patients

Timeline

Start: 2019-01-14
Primary completion: 2020-04-03
Completion: 2020-04-03

Publications

Results Usmani OS, Baldi S, Warren S, Panni I, Girardello L, Rony F, Taylor G, DeBacker W, Georges G. Lung Deposition of Inhaled Extrafine Beclomethasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide in Healthy Volunteers and Asthma: The STORM Study. J Aerosol Med Pulm Drug Deliv. 2022 Aug;35(4):179-185. doi: 10.1089/jamp.2021.0046. Epub 2022 Feb 4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Formoterol	Other / unclassified	24 ug	Inhaled
Subject	Glycopyrronium	Unknown	50 ug	Inhaled
Subject	beclomethasone dipropionate	Other / unclassified	400 ug	Inhaled

Lung Deposition of TRIMBOW® pMDI in Healthy Volunteers, Asthmatic and COPD Patients

Summary

Timeline

Publications

Drugs

Indications